Technical Reference #927

927.

Simvastatin Inhibits Staphylococcus Aureus Host Cell Invasion Through Modulation Of Isoprenoid Intermediates Mary P. Horn; Sharmon M. Knecht; Frances L. Rushing; Julie Birdsong; C. Parker Siddall; Charron M. Johnson; Terri N. Abraham; Amy Brown; Catherine B. Volk; Kelly Gammon; Derron L. Bishop; John L. McKillip; and Susan A. McDowell, Ball State University, Journal of Pharmacology and Experimental Therapeutics, 326(927), (2008)
Link To Paper

Abstract:
Patients on a statin regimen have a decreased risk of death due to bacterial sepsis. We have found that protection by simvastatin includes the inhibition of host cell invasion by Staphylococcus aureus the most common etiologic agent of sepsis.

Keywords:
simvastatin; sepsis; isoprenoid intermediates; prenylation

Materials & Methods:
For confocal imaging cells were plated on 35-mm glass-bottom dishes (MatTek Ashland MA) and coated as described above.

Microscopic Technique
Confocal Microscopy

Cell Type(s)
HUVEC