Technical Reference #771

771.

A-Induced Meningoencephalitis Is Ifn-Dependent And Is Associated With T Cell-Dependent Clearance Of A In A Mouse Model Of Alzheimer’S Disease Alon Monsonego*; Jaime Imitola‡; Sanja Petrovic‡; Victor Zota‡; Anna Nemirovsky*; Rona Baron*; Yair Fisher*; Trevor Owens§; and Howard L. Weiner, Ben-Gurion University, PNAS, 103(771), (2006)
Link To Paper

Abstract:
Vaccination against amyloid -peptide (A) has been shown to be successful in reducing A burden and neurotoxicity in mousemodels of Alzheimer’s disease (AD). However although A immunizationdid not show T cell infiltrates in the brain of these micean

Keywords:
amyloid -peptide encephalitis vaccination

Materials & Methods:
Microglia were cultured on MatTek Petri dishes for 24 h in the presence and absence of IFN-g.

Microscopic Technique
Confocal Microscopy

Cell Type(s)
Neurons - Hippocampal