Technical Reference #759

Glass Bottom Culture Dishes

This study used MatTek product(s):

Citation in paper containing MatTek reference:
glass bottom dishes (MatTek; Ashland; MA)

759.

Activation Of Amp-Activated Protein Kinase By Human Egf Receptor 2/Egf Receptor Tyrosine Kinase Inhibitor Protects Cardiac Cells Neil L. Spector*; Yosef Yarden; Bradley Smith‡; Ljuba Lyass§; Patricia Trusk§; Karen Pry§; Jason E. Hill§; Wenle Xia*; Rony Seger; and Sarah S. Bacus, Duke University, PNAS, 104(759), (2007)
Link To Paper

Abstract:
The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes and its inhibition mayexplain the increased incidence of cardiomyopathy associated withthe anti-HER2 monoclonal antibody trastuzumab (GenentechSo

Keywords:
monoclonal antibodies

Materials & Methods:
Au565 MCF7 MCF7/HER2 and HMCs cells were seeded on glass bottom dishes (MatTek Ashland MA) the day before the experiment.

Microscopic Technique
Confocal Microscopy

Cell Type(s)
Au565, MCF7, HER2, and HMCs