Technical Reference #399

399.

U2: Combined Ultrasonic Microscopy And Ultrafast Optics For Molecular Imaging And Therapy M. O’Donnell; C. Tse; M. Zohdy; T. Erpelding; K. Hollman; JY Ye; T. B. Norris; and L. Balogh, University of Michigan, 2004 IEEE Ultrasonics Symposium, (2004)
Link To Paper

Abstract:
We have developed an approach tomolecular detection in which a nanoscale objectsimilar to important biological macromolecules istransduced by a very short (femtosecond) laser pulseinto a microscale object directly detectable withultrasound. Our specific e

Keywords:
laserinduced optical breakdown (LIOB); Dendrimers

Materials & Methods:
CHO-K1 (Chinese hamster ovary) cells were used as the in vitro target tissue for laser photodisruption. Cells were cultured in a self-adherent monolayer on a No. 0 coverslip in a glass-bottom culture dish (MatTek Corporation Ashland MA) and grown to ap

Microscopic Technique
Ultrasonic Microscopy

Cell Type(s)
CHO