Technical Reference #200

200.

Generation Of Neuronal Intranuclear Inclusions By Polyglutamine-Gfp: Analysis Of Inclusion Clearance And Toxicity As A Function Of Polyglutamine Length Moulder;K.; Onodera;4; O.; Burke;4;J.; Strittmatter;;4;W.; Johnson; E., Washington University, The Journal of Neuroscience, 19(200), (1999)
Link To Paper

Abstract:
Recent evidence suggests that in huntingtin and many other proteins polyglutamine repeats are a toxic stimulus in neurodegenerative diseases. To investigate the mechanism by which these repeats may be toxic we transfected primary rat cerebellar granule

Microscopic Technique
Fluorescence microscopy

Cell Type(s)
Cerebellar