Technical Reference #1586

Glass Bottom Culture Dishes

This study used MatTek product(s):

Citation in paper containing MatTek reference:
glass-bottom-dishes (Mattek; Ashland; MA; USA)

1586.

Pak Kinase Regulates Rac Gtpas And Is A Potential Target In Human Schwannomas Christine Flaiz; Jonatthan Chernoff; Sylwia Ammoun; Jeffrey R. Peterson; Clemens Oliver Hanemann, Peninsula College for Medicine, Experimental Neurology, 218(1586), (2009)

Abstract:
Merlin loss causes benign tumours of the nervous system mainly schwannomas and meningiomas.Schwannomas show enhanced Rac1 and Cdc42 activity the p21-activated kinase 2 (PAK2) activation andincreased ruffling and cell adhesion. PAK regulates activati

Keywords:
Schwannoma; PAK; Merlin; Small GTPase

Materials & Methods:
Schwann cells were obtained from peripheral nerves from tissue donors not carrying any predisposition to a peripheral neuropathy.

Microscopic Technique
Confocal Microscopy

Cell Type(s)
Schwannoma, Schwann Cells