Technical Reference #1567

1567.

Capon Modulates Cardiac Repolarization Via Neuronal Nitric Oxide Synthase Signaling In The Heart Kuan-Cheng Chang, Anfreas S. Barth, Tetsuo Sasano, Eddy Kizana, Yuji Kashiwakura, Yiqiang Zhang, D. Brian Foster, Eduardo Marban, The Johns Hopkins University, China Medical University and Hospital, Cedars Sinai Medical Center, PNAS, 105(1567), Supporting Info, (2008)
Link To Paper

Abstract:
Congenital long- or short-QT syndrome may lead to life-threateningventricular tachycardia and sudden cardiac death. Apart fromthe rare disease-causing mutations, common genetic variants inCAPON, a neuronal nitric oxide synthase (NOS1) regulator, hav

Keywords:
NOS1, QT interval, cardiac electrophysiology

Materials & Methods:
Total RNA was extracted from the ventricular myocardium of adult guinea pig with an RNEasy mini kit (Qiagen) according to the manufacturer's instructions and then quantified by a UV spectrometer.

Microscopic Technique
Confocal Microscopy

Cell Type(s)
HEK-293