Technical Reference #144

144.

Histone-Gfp Fusion Protein Enables Sensitive Analysis Of Chromosome Dynamics In Living Mammalian Cells Kanda; T.; Sullivan*; K.; Wahl G.;, The Salk Institute for Biological Studies, Current Biology, 8(144), (1998)
Link To Paper

Abstract:
The amplification of oncogenes in cancer cells is often mediated by paired acentric chromatin bodies called double minute chromosomes (DMs) which can accumulate to a high copy number because of their autonomous replication during the DNA synthesis phase

Microscopic Technique
Confocal Microscopy

Cell Type(s)
HeLa