Technical Reference #1424

1424.

Megakaryocyte Endomitosis Is A Failure Of Late Cytokinesis Related To Defects In The Contractile Ring And Rho/Rock Signaling Larissa Lordier; Abdelali Jalil; Fréderic Aurade; Fréderic Larbret; Jerôme Larghero; Najet Debili; William Vainchenker; and Yunhua Chang, Inserm, Blood, 112(1424), (2008)
Link To Paper

Abstract:
Megakaryocyte (MK) is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis which was a process considered to be an incomplete mitosis aborted in anaphase.

Materials & Methods:
Cells were subsequently seeded in glass bottom culture dish (MatTek Ashland MA).

Microscopic Technique
Confocal Microscopy, Laser Scanning

Cell Type(s)
Megakaryocytes